During Bairam Khan's regency, the territories of the Mughal empire had been expanded rapidly. Apart from Ajmer, an important conquest during this period was that of Malwa.
- Malwa was being ruled, at that time, by a young prince, Baz Bahadur. His accomplishments included a mastery of music and poetry.
- Stories about the romance of Baz Bahadur and Rupmati, who was famous for her beauty as well as for music and poetry, are well known. During his time, Mandu had become a celebrated centre for music.
- The army, however, had been neglected by Baz Bahadur. The expedition against Malwa was led by Adham Khan, son of Akbar's foster-mother, Maham Anaga.
- Baz Bahadur was badly defeated (1561) and the Mughals took valuable spoils, including Rupmati. However, she preferred to commit suicide to being dragged to Adham Khan’s harem.
- Due to the senseless cruelties of Adham Khan and his successor, there was a reaction against the Mughals which enabled Baz Bahadur to recover Malwa.
- After dealing with Bairam Khan's rebellion, Akbar sent another expedition to Malwa. Baz Bahadur had to flee, and for some time he took shelter with the Rana of Mewar. After wandering about from one area to another, he finally repaired to Akbar’s court and was enrolled as a Mughal mansabdar. The extensive country of Malwa thus came under Mughal rule.